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Published:2024-06-19  Views:191

SPEAKERGENG TIAN

                 Tenure-track Associate Professor, Ph.D.

                 Department of Food Science & Engineering, SAB

 

TIME :12:40-14:00 Jun 26, 2024 (Wed)

 

VENUE:Room 104, Building B, SAB

 

ORGANIZER:Office of Discipline and Science & Technology, SAB;

                             Young Teachers Association, SAB

 

TITLE:3D Genome Structure Shapes the Recombination Landscape of Chromatin Features in Germline Stem Cell Development

 

ABSTRACT

  High-throughput chromatin conformation capture (Hi-C) technology focuses on the nucleus, investigating the spatial relationships of chromatin throughout the entire genome, and obtaining high-resolution maps of chromatin regulatory elements' interactions, comprehensively elucidating chromatin's three-dimensional structure. Studying the recombination patterns of chromatin's three-dimensional structure during germline development aids in a deeper understanding of the transcriptional regulatory mechanisms of genes during its developmental process. The speaker mainly introduces the chromatin's higher-order structure unique to the female germline stem cells (FGSCs) and key regulatory factors through techniques such as Hi-C, ChIP-seq, and ATAC-seq, and outlines the patterns of chromatin's higher-order structural changes during FGSC development.  

 

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Support by: Wei Cheng

Support by: Wei Cheng